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RBCs normally contain a high concentration of bioavailable or free heme, as shown by dialysis experiments [230], derived by the auto-oxidation of 300 million molecules of hemoglobin in each RBC

AEs leading to trial product discontinuation occurred in 6/90 (7%) participants in the CagriSema 2.4 mg/2.4 mg group, 11/93 (12%) participants in the CagriSema 1 mg/1 mg group, and 1/91 (1%) in the placebo group