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[12] While routine dietary or prenatal vitamin levels of pyridoxine are clearly safe and beneficial in pregnancy, extremely high pharmacological doses are not routinely advised unless there is a clear medical indication

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Even mild dehydration can impair physical and cognitive performance, manifesting as fatigue, difficulty concentrating, and reduced exercise capacity

"Semaglutide 2.4 mg once a week in adults with overweight or obesity and type 2 diabetes." Lancet