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The different outcomes may therefore be explained by the use of different dosing and different mouse strains
[18] While PLC1 is well documented and easily found in the body, clear connections and roles for PLC1 have been difficult to find in in vivo studies

(B) U73122 treatment significantly decreased IL-1-induced expression of p-Akt and p-p38 in GO fibroblasts, whereas (C) IL-1-induced expression of p-Akt and p-JNK was significantly decreased in normal orbital fibroblasts

CrossRef Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications Xuan Trong Truong, Dae Ho Lee Diabetes & Metabolism Journal.2025