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Mol Cancer Res 16:10731076 Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH (2020a) Sqstm1/p62 activates nfe2l2/nrf2 via ulk1-mediated autophagic keap1 degradation and protects mouse liver from lipotoxicity

In addition to mitochondrial OxS (as detailed below), there are numerous sources of endogenous OxS (e.g., inflammatory responses) that can be relevant to T2D progression [87]

Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine -lyase (CTH)
Furthermore, the endothelial dysfunction caused by Long COVID can lead to microvascular clotting and poor tissue perfusion
