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Specifically, the peptide downregulates inflammatory genes including interleukin-1, tumor necrosis factor-, and nuclear factor-B, while upregulating protective genes such as those encoding antioxidant enzymes, DNA repair proteins, and extracellular matrix components

Walker, R.D., Stein, G

The significant increase in serum ALT, AST, and ALP levels observed in rats exposed to high altitudes indicates hypoxia-induced mild hepatocellular leakage and loss of membrane integrity

RSL3-treated Treg cells accumulated lipid peroxides and died through a resultant ferroptosis, suggesting that Gpx4 is integral to maintaining Treg cell homeostasis