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however, its utilization significantly declined following findings from the Heart and Estrogen/Progestin Replacement Study (HERS) (161)and the Womens Health Initiative (WHI) (162, 163) randomized trials

GABA is crucial for balancing excitatory and inhibitory neurotransmission, essential for normal brain function and mental health
Central command dysfunction in rats with heart failure is mediated by brain oxidative stress and normalized by exercise training

Ketogenic diets as treatment of obesity and type 2 diabetes mellitus
