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Here, we profile key ferroptotic defence strategies including iron regulation, phospholipid modulation and enzymes and metabolite systems: glutathione reductase (GR), Ferroptosis suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), Dihydrofolate reductase (DHFR), retinal reductases and retinal dehydrogenases (RDH) and thioredoxin reductases (TR)

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In this study, molecular modelling techniques were employed, including high-throughput virtual screening (HTVS), followed by filtration procedures such as Lipinskis rule of five and Vebers rules, and finally CDOCKER docking, to prioritize compounds from the commercial Maybridge database

Lcarnitine seems to have a pivotal role in cardiovascular health due to its energy metabolism, anti-oxidative stress, and endothelial role