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Thesignsandsymptomsof thedeficiencymay include anemia , the buildup of too much acid in the body (metabolic acidosis), frequent infections, andsymptomscaused by problems in the brain including seizures , intellectual disability , and loss of coordination ( ataxia )

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In the present analysis, the transcription of the genes coding for the antioxidant defense elements are viewed in the time-frame of the intraerythrocytic cycle
