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Hanno PM, Buehler J and Wein AJ: Use of amitriptyline in the treatment of interstitial cystitis

The "vs" framing oversimplifies what is really a choice of pathway: pick MOTS-c to study energy and mitochondrial signaling, Epithalon to study the telomere clock, or both to span the two hallmarks

The absence of standardized protocols and long-term safety data means that patients must navigate this treatment option with heightened caution and informed consent
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