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Experimental studies further show that these fibrils are structurally stable and highly neurotoxic, their introduction into the colon reproduced key motor and cognitive deficits associated with PD [134, 135], underscoring the role of secretase as a molecular link between peripheral inflammation and central neuropathology

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Therefore, we compared the risk of composite bleeding outcomes between patients treated with DOACs combined with telmisartan, which has high P-gp inhibitory activity among ARBs, and olmesartan, which has low P-gp inhibitory activity among ARBs