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Igf-2 but not Igf-1 is involved in neuronal survival of newly generated neurons in the adult DG in a model of fear extinction, that is strongly associated with neurogenesis in the hippocampus [31]

As an example, it has been demonstrated that a mutation (S662G) in PER2, which is known to be responsible for the familial advanced sleep phase syndrome, increased resistance to apoptosis and E1A- and RAS-driven oncogenic transformation, as well as affected tumorigenesis in p53 R172H/+ mice, with a cancer-sensitized genetic background 38

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AMPK can also directly inhibit ACC2, decrease malonyl Co-A, and activate carnitine palmitoyl transferase 1 (CPT1), and thereby enhancing -oxidation