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Trimethylamine-N-Oxide promotes vascular calcification through activation of NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-B (nuclear factor B) signals

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A meta-analysis of metabolic studies showed that both a catechin-caffeine mixture and caffeine alone dose-dependently stimulated daily energy expenditure, but only the catechin-caffeine combination significantly increased fat oxidation [41]

If tea could prevent or delay the development of these diseases, then the public health implications would be tremendous