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Major contributors to ROS production include mitochondrial dysfunction, cytochrome P450 2E1 (CYP2E1), and NADPH oxidase (NOX) enzymes

The fourth step of the mechanism consists of a second Tyr9 rearrangement that allows direct interaction of the Tyr9 phenolate with the glutathione thiol
[DOI] [PubMed] [Google Scholar] 109.De Pergola G., Triggiani V., Bartolomeo N., Giagulli V.A., Anelli M., Masiello M., Candita V., De Bellis D., Silvestris F

doi: 10.7150/ijbs.41051 102 LiXGracillaDCaiLZhangMYuXChenXet al