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J Trace Elem Med Biol 54:226231 [DOI] [PubMed] [Google Scholar] Kim Y, Iwai T, Fujii S, Ueno K, Sawamura M (2021) Dumbbell-shaped 2,2-bipyridines: controlled metal monochelation and application to Ni-catalyzed cross-couplings

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Acute glycolytic flux generates lactate that acidifies the microenvironment, proton loads inactivating sirtuin deacetylases to impair peroxisome proliferator-activated receptor gamma coactivator 1 alpha-mediated mitochondrial biogenesis [71] while activating calcium-independent phospholipase A 2 to liberate arachidonic acid [72]