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10.1007/s13346-018-00613-y [DOI] [PubMed] 15.Parry Strong A, Haeusler S, Weatherall M, Krebs J (2016) Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomized trial

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A small subset of "sentinel" participants is dosed first, before the rest of the cohort, as an additional safeguard

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