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In cases where oral appliance therapy is not sufficient on its own to alleviate your symptoms, it can be a great complement to CPAP, and even make CPAP more tolerable as a much lower air pressure can be effective than without the oral appliance
Recent cloning of the COL5A3 gene will make possible mutational analysis of this gene (16), but it is unlikely that all remaining cases of classical EDS will be accounted for by COL5A3 mutations
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In the second step, we use the equilibrium equation (Equation 16.15) to determine [H + ] of the resulting solution
