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One of the approaches to enhance soluble expression is co-expression of protein chaperones [14]
Iron deficiency per se and iron deficiency-induced hypoxia can trigger the activation of HIFs, which are known to mediate cancer progression by upregulating target genes associated with angiogenesis and the metabolic reprogramming of tumor cells (106, 107), thus causing resistance to chemo- and radiotherapies (108, 109)
subtilissignificantlyreduced the incidence of antibiotic-associated diarrheain patients, andprevented nausea, bloating, vomiting and abdominalpain[9]
[DOI] [PubMed] [Google Scholar] 67.Fukushige S., Horii A
