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In my own practice, especially if an older person has risk factors for vitamin B12 deficiency, I consider a vitamin B12 level of 200-400 pg/mL borderline, and I usually order a methylmalonic acid level as a follow-up

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For instance, fatigue-induced changes in biomechanics, such as increased knee valgus (inward collapse of the knee) and internal rotation, are associated with a higher risk of ACL injuries