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Factors affecting individual response include baseline tissue health, severity of issues being addressed, consistency of use, lifestyle factors, current medications, and genetic variables

Initial treatment often involves more frequent injections (weekly or biweekly), potentially transitioning to monthly maintenance as levels stabilise

Age compounds the problem

While traditionally regarded as a vitamin B clearance enzyme, over the past decade NNMTs role has expanded dramaticallyto include reprogramming onecarbon metabolism, impacting NAD levels, DNA/histone methylation, and even tumor progression and angiogenesis