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Yet, these therapies fail in many patients for a variety of reasons, including CD8 + T cell exhaustion and immunosuppression by the TME due to low oxygen and competition for nutrients between tumor cells and immune cells (126)
and Ratlalan, B
Al-Dewik N, Ali A, Mahmoud Y, Shahbeck N, Ali R, Mahmoud L, et al
Nat Genet 50(8):11121121
