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Any impairment in the activity of glycolytic enzymes might trigger flux rerouting towards antioxidant production e.g., to the PPP for NADPH regeneration (and with it, glutathione recycling via glutathione reductase (GR)) or to serine-biosynthesis 36 (Fig

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However, evidence for an age-related decline in NAD + levels in humans has been consistently observed only in a limited number of studies
