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NNMT inhibition doesn't directly affect gut motility, so prolonged GI symptoms suggest an individual sensitivity rather than a universal mechanism

And none of my GPs (3 to date as ive moved around) and my Endocrinologist also doesn't know why

ERG inhibits polyphenoloxidases (527) , and thus ERG has been used in the feed of the shrimp Marsupenaeus japonicas to prevent melanosis during storage (528) , while ERG-rich mushroom extract has also been used to prevent melanosis in post-harvest storage of the crab Chionoecetes japonicus (529)

For research requiring minimal systemic effects, AOD9604 may be preferable
