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J Clin Endocrinol Metab 79 : 205210 Moses AC et al
When cartilage degrades due to aging, repetitive stress, injury, or inflammatory conditions, the body struggles to replace what has been lost
Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors
notably, the proportion of patients with weight gain during the study was substantially higher in the placebo group
