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Description
However, etorphine, [Leu 5 ]- and [Met 5 ]-enkephalins rather promote a recycling of hDOR while DPDPE, Deltorphin I or SNC-80 induce a degradation and a down-regulation (Marie et al., 2008): when the receptor is phosphorylated by GRK2 and internalized via arrestins it can recycle whereas in a non-phosphorylated form DOR undergoes an arrestin-independent sequestration which is followed by a degradation
Challenges and Perspectives of Neurological Disorders
Nature 520, 5762 (2015)
[Abstract]2024 Sep;131(4):763-777
