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Long-term GH elevation in acromegaly patients demonstrates potential complications including joint issues, cardiomegaly, and insulin resistance
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Clin Biochem (2013) 46(10-11):8425
Another NAM analog-based NNMT inhibitor, 6-methoxy NAM (also known as JBSNF000088), has shown promise in decreasing body weight and enhancing insulin sensitivity in mice models of obesity induced by a high-fat diet 198
