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Baez S, Segura-Aguilar J, Widersten M, Johansson AS and Mannervik B

In renal biopsy tissue studies of CKD patients and mice models including UUO and renal ischemia-reperfusion injury, downregulation of GPx4 and upregulation of 4-hydroxynonenal were observed

Of course, each of these meta-analyses included differing collections of studies, depending on their investigational aims and inclusion/exclusion criteria, and this factor may be all important in dictating the eventual results

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