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Des tudes se concentrent notamment sur la neutralisation des radicaux libres , ainsi que sur la rgulation de l' homostasie du zinc pour favoriser la neuroprotection aprs une ischmie-reperfusion

Annexin V/propidium iodide staining confirmed an increase in apoptosis, and real-time PCR demonstrated reduced mitochondrial cytochrome C mRNA levels [30], suggesting activation of the intrinsic apoptotic pathway

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This phenomenon was first described by Lemasters group [37] when APAP-induced MPTP opening and necrotic cell death in primary isolated hepatocytes was attenuated by MPTP inhibitors at early time points but not late time points where caspase activation was detected