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It is a relatively rare disorder, diagnosed in approximately 1 in 250,000 births worldwide
Control of the activity of mitochondrial enzymes by reversible lysine acetylation The mitochondrial presence of several nicotinamide adenine nucleotide (NAD + )-dependent deacetylase silent information regulators (sirtuins, SIRT3, 4, and 5) recently has been described [146148]
