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3.1 Mitochondria-associated metabolic reprogramming of macrophages Mitochondria serve as the central hub for macrophage metabolic plasticity, which plays an important role in energy production, immune regulation, signal transduction, and cell fate determination, intervening the inflammation regulation and macrophage repair ( 1 % ( 3.1.1 ROS and oxidative stress Chronic exposure to cigarette smoke extracts (CSE) or particulate matter resulted in elevated oxidative stress, a critical metabolic characteristic in AMs of COPD patients ( Subsequent research indicated that AMs from COPD patients exhibited impaired phagocytosis associated with mitochondrial dysfunction ( 2 O 2 and hydroxyl radicalsOH)
