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Prospects for treatment of free radical-mediated tissue injury

The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

Potential side effects include: Injection site reactions, including redness, swelling, bruising, pain, or irritation Mild fluid retention (edema) Joint or muscle discomfort Headache, dizziness, or flushing Changes in glucose regulation, particularly in individuals with diabetes or prediabetes Itching, restlessness, drowsiness, nausea, or difficulty swallowing (3) Importantly, the occurrence of potential side effects does not predict an individual's overall response to therapy

The following factors may increase the likelihood of having a B12 deficiency