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MOTS-c seems to activate AMPK

Evidence from studies in vivo suggests that androgen deficiency is closely associated with decreases in ATP synthesis and the activity of complexes I and III in the hippocampus and substantia nigra of castrated male rats (84), which was improved by exogenous testosterone supplementation (122)

[DOI] [PubMed] [Google Scholar] 23.Bolker B.M., Brooks M.E., Clark C.J., Geange S.W., Poulsen J.R., Stevens M.H., White J.S