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J Biol Chem 281:3986039869

JHU083, another novel DON prodrug developed in recent years, has shown a remarkable tumor growth inhibition effect in various tumors (Hanaford et al., 2019
Thats a real thing, and its caused by hydrogen peroxide not applied from the outside, but produced from within

In agreement with our results in the liver, we observed significantly higher betaine, and a trend for higher glycine in the kidney of KD mice, but no differences in DMG or methionine were observed (Fig