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Patients who are pregnant, breastfeeding, have complex medical conditions, untreated sleep disorders, cardiovascular concerns, psychiatric instability, autoimmune concerns, or multiple medication interactions should be especially cautious

Prednisolone: Although prednisone has reduced the mineralocorticoid effect, the risk of hypokalemia exists and must be taken into account in particular in the following situations: - when potassium-losing diuretic, laxative or amphotericin B have been given concomitantly or when the patient has vomiting or diarrhea

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