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Weight loss : Both can lead to weight loss as a secondary benefit

In gram-negative bacteria, there is a Resistance-Nodulation-Division family (RND), along with ABC and MFS 77

CD44 signaling activates oxidative stress pathways, induces HIF1-driven metabolic shifts under hypoxia, and promotes epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose polarity and cell-cell adhesion while acquiring mesenchymal traits, leading to increased motility and invasiveness

doi: 10.1038/s41568-019-0118-8