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USA 120 , e2214505120 (2023)
(NIH) In adults over 55 with type-2 diabetes, GSH supplementation improved glutathione stores and reduced DNA oxidative damage (8-OHdG) while lowering HbA1c.(NIH) However, short-term trials (4 weeks) in healthy adults showed no measurable change in blood GSH, highlighting absorption variability
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Cardiometabolic diseases (e.g., heart failure, T2D, hypertension) accelerate frailty, and conversely, frailty predicts worse cardiovascular and cognitive outcomes [38]
