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These observations are in contrast to previous findings in the same Nrf2-GFP-HepG2 reporter model exposed to DEM or tert -butylhydroquinone, which indicate a lower Nrf2 response toward repeated treatments (Bischoff et al
Springer Link , Seminars in Liver Disease , vol
Hypoxia-inducible factor-1 (HIF-1) has been shown to play a critical role in the cellular response to oxygen deprivation during testicular IR injury 6,7,8
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