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By diminishing the DNA binding capacity of hypoxia response elements in Caco-2 and IEC-6 cells, contradictory findings suggest that butyrate suppresses the transcriptional activity of HIF-dependent hypoxia-sensitive genes 79
Interestingly, more blast phase CML, a more advanced phase biologically more similar to acute leukemia, is relatively insensitive to the GVL effect of DLI, further underscoring the so far undefined contribution of disease biology to success or failure of GVL (46, 59, 60)
10.3109/09637480903286363 136 ZhangD.LiptonS
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