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Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

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The interaction of TJ proteins with the actin cytoskeleton is vital to the maintenance of TJ structure and permits the cytoskeletal regulation of TJ barrier integrity.17 The circumferential contraction and tension in the actin is regulated by myosin light chain (MLC) activation.18 Induction of MLC phosphorylation by kinases such as MLC kinase (MLCK) and Rho-associated kinase causes the contraction of the actin, resulting in the opening of the paracellular pathways.18,19 1

However, recent studies (2026) have shown that the mitochondrial pyruvate carrier (MPC) complex is involved in the mitochondrial export of lactate