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VDAC opening enhances mitochondrial membrane permeability, leading to glutathione (GSH) depletion and ROS accumulation, thereby accelerating ferroptosis [32]
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Interestingly, one of the pathways previously mentioned as a potential target as treatment for DPN, the Nrf2 signaling cascade, serves as a major regulator of antioxidant response elements [88]
Cardiovascular events, diabetes, psychological factors, and obesity are major contributors to ED, making it essential to adopt healthier habits and therapeutic approaches for sustained results
