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These observations clearly support the anticancer effects of polyphenols by changes in the cancer cells epigenome [180]
Metabolomic profiling indicated significant alterations in amino acid metabolism, nicotinic acid and nicotinamide metabolism, purine metabolism, sugar metabolism, and alkaloid biosynthesis pathways
In another interesting observation, Chandel and colleagues reported that mitochondrial ROS play a major role in HIF-1 regulation [75]
doi: 10.3109/15563659209017937
