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In people with a genetic disorder affecting intracellular vitamin B12 metabolism, hydroxycobalamin achieves the best results (Obeid et al., 2015

Starting low is not being conservative

Individual Biology Age, genetics, and baseline epithelial turnover rates affect how quickly renewal and signaling stabilize
This work was supported by grants from the American Heart Association (RG: AHA916225, ANT: AHA.24CDA1276505.pc.gr.193648, and ST: AHA CDA941290), the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295
