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A prominent player in cytokine-mediated tight junction regulation is myosin light chain kinase (MLCK) 56,65,66 , which disrupts the interaction between the tight junction proteins and the actin-myosin cytoskeleton, subsequently damaging the tight junction scaffold, which is crucial for the maintenance of barrier integrity 66,67,68

Tannock IF, 2024, 'Correction to: Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity (Cancer Chemotherapy and Pharmacology, (2017), 79, 5, (959-969), 10.1007/s00280-017-3298-5)', Cancer Chemotherapy and Pharmacology , 94, pp

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