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It is believed that the redox homeostasis in the ER may result in ER-associated stress, which may trigger redox signaling mediators playing roles in ROS formation and consequently in the pathogenesis of various human disorders
Ringeisen, B
14 CaldasT.MalkiA.KernR.AbdallahJ.RicharmeG
Third hit: A synergistic injury network that evolves on the basis of the second hit, encompassing multiple pathological factors such as lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, adipose tissue-derived inflammatory factors, and gut microbiota-derived endotoxins
