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Regarding microbiota, in individuals with cancers other than prostate, colorectal, or ovarian malignancies, Proteobacteria, the number of the Firmicutes phylum, and Actinobacteria were increased compared to healthy donors (Kostic et al., 2012

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These casts form in the renal tubules due to the intense interstitial inflammation and localize the pathology to the tubulointerstitium rather than the glomerulus