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The unusually lipid-rich diderm structure of the mycobacterial cell envelope, initially proposed by Minnikin in 1982 (99), was visualized in 2008 by cryo-electron microscopy of M
the three most common phenotypes are: PiM (medium), PiS (slow), and PiZ (very slow) ( Severe A1AT deficiency (A1ATD) is associated with specific variants, such as Z- or S- types, which can result in the early onset and sever development of emphysema, liver disease, and, rarely, multiorgan vasculitis and necrotizing panniculitis ( A1AT is abundant in the plasma with a mean concentration of 1.3 g/L and a plasma half-life of 4-5 days
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CNS endothelial cell activation emerges as a driver of CAR T cell-associated neurotoxicity
