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We design and select the most suitable linker based on the efficacy and toxicity of an individual ADC module to deliver high-quality and low-cost linker products in time

Safety assessment of the LAB strains Hemolysis assay The hemolytic activity of the selected LAB strains was determined according to Maragkoudakis et al

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Association of Hcy-axes with mitochondrial dysfunction Mitochondria are essential for maintaining cellular homeostasis and function, primarily in oxidative phosphorylation (OXPHOS), and for regulation of ion homeostasis, redox potential, lipid metabolism, metabolite synthesis, cell differentiation, immune system, anti-apoptotic, and anti-aging mechanisms [63]