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This is a necessary step in separating damaged mitochondria before they are engulfed by autophagosomes
9 Lipophilicity is particularly relevant for drugs with molecular weights ranging from 300 to 1000 Da

Langhi C, Pedraz-Cuesta E, Haro D, Marrero PF, Rodriguez JC

Tingling or numbness: Temporary sensations of tingling, burning, or itching in the skin (known as pins and needles) result from changes in peripheral nerve signaling