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Chin J Behav Med Sci
SAM, S-adenosylmethionine
Notably, alterations in the binding of AP-1 family members, such as FRA-2 and JUND, were closely linked to increased DNA methylation, suggesting that mutant HTT may disrupt normal transcriptional regulation (212)
It is thought to reduce the production of prostaglandins (chemicals that cause inflammation) in the brain and to lower fever through its action on heat-regulating centers in the brain but the precise mechanism remains unclear
