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Similarly, 4-HNE interacts with proteins, phospholipids, and DNA, impairing cellular function and modulating pathways involved in survival, apoptosis, and inflammation [86]
Indeed, it was shown that administration of aspartame at high doses (250 and 1000 mg/kg) for eight weeks produced remarkable liver fibrosis and changes in the mRNA levels of crucial oncogenes and tumor suppressor genes, including Harvey rat sarcoma viral oncogene homolog upregulation and P27 downregulation, respectively, indicating its potential risk in progressing to liver cancer [8]
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Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake
