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the metabolic features of distinct regions are likely indicative of tumor aggressiveness and treatment susceptibility ( 2 Core pathways and molecular basis of metabolic reprogramming 2.1 VHLHIF axis-driven glucose/carbon metabolism pathway reprogramming VHL gene mutation or inactivation is one of the most common molecular characteristics of ccRCC

10.1371/journal.pone.0017287 PLoS One 269 SegnitzN.SchmittA.Gebicke-HrterP

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Published studies have reported enhanced angiogenesis, reduced inflammatory marker expression, and accelerated wound closure in preclinical models